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Quality Factors Affecting Hematology Analyzer's Test Results

Because of its accuracy and speed, hematology analyzers have been popularized in China, and are deeply loved and trusted by medical workers and patients. They have replaced manual counting in daily work, and have significantly improved the speed and quality of blood analysis.

A laboratory worker, after using the hematology analyzer for a long time, found that in addition to the maintenance, calibration and quality control of the instrument, there are still some conditions that affect the test results of the hematology analyzer. After observation, it was found that the following three major random factors seriously affect the accuracy and precision of the test results, which should be paid attention to.

These three conditions are random and frequent adverse conditions that affect the blood analysis quality of the hematology analyzer, but these conditions have not been paid much attention to. In order to control the test results of the instrument in a good and stable state and further improve the quality of blood analysis, the performance and treatment measures of these three conditions are reported as follows:

1. Platelet and red blood cell aggregation affects the hematology analyzer

Aggregation of platelets and red blood cells, whether due to irregular blood collection or other reasons, is shown on the values and histograms of the hematology analyzer.

The most obvious manifestations are the increase of the total number of leukocytes, the decrease of the total number of platelets, the elevation of the left side of the dashed line on the leukocyte histogram to varying degrees, and the histograms of leukocytes and platelets have different degrees of sawtooth-like changes when the aggregation is severe.

The aggregation of platelets and red blood cells mainly occurs in peripheral blood samples. As long as there is a small amount of tissue fluid, ethanol components and blood collection time is too long during the blood collection process, the aggregation of platelets and red blood cells may occur. After observation, it was found that the best solution is to use standard vacuum blood collection tubes for venous blood collection.

2. Air bubbles affect the hematology analyzer

Excessive and violent shaking during blood collection or before analysis can not only rupture cells, generate cell debris, affect platelet count, but also generate a large number of tiny bubbles.

During analysis, once the tiny air bubbles are sucked into the analyzer, the small air bubbles can be analyzed as cellular components, and the value increases; the larger ones will temporarily block the analysis holes, reduce the count, and the count result is low, and even cause false alarms of the liquid flow of the instrument. . This kind of alarm is not specific, the analysis is more difficult, and it should be avoided as much as possible in the work.

3. Maintenance problems affect the hematology analyzer

Instrument maintenance is an important part of the use of the hematology analyzer. Everyone needs to do instrument maintenance and background count detection when it is just turned on and after a long period of deactivation. The quality control has been done well. However, the problem lies in the testing process. After the sample, if the maintenance of the hematology analyzer and the monitoring of the background count are not carried out, the flow path will be dirty, the counting holes will become smaller, the background count will increase, and the test result will be high; if the background count is not carried out, the flow path will be Uncleanness can not be found in time, and the subsequent test results are all high, especially the impact on platelet count is the most significant.

Therefore, after a certain amount of samples is detected during the detection process, a background count monitoring must be performed in order to detect flow path problems and deal with them in time.

The above influencing factors appear frequently. The first two factors mostly affect the test results of a single specimen, and the latter factor will affect all test results from the time the instrument is dirty to before it has been cleaned.

As long as the operation of the instrument, the alarms in the blood analysis report and the changes in the histogram are observed at any time, it is not difficult to find the influence of the above factors on the blood analysis results. As long as the influencing factors in the above three aspects are well controlled, the influencing factors that often appear in daily work can be controlled, and the test results of the hematology analyzer will be more accurate and reliable.

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